Design and estimation in clinical trials with subpopulation selection
نویسندگان
چکیده
منابع مشابه
Estimation after subpopulation selection in adaptive seamless trials
During the development of new therapies, it is not uncommon to test whether a new treatment works better than the existing treatment for all patients who suffer from a condition (full population) or for a subset of the full population (subpopulation). One approach that may be used for this objective is to have two separate trials, where in the first trial, data are collected to determine if the...
متن کاملEstimation of Subpopulation Parameters in One-stage Cluster Sampling Design
Sometimes in order to estimate population parameters such as mean and total values, we extract a random sample by cluster sampling method, and after completing sampling, we are interested in using the same sample to estimate the desired parameters in a subset of the population, which is said subpopulation. In this paper, we try to estimate subpopulation parameters in different cases when one-st...
متن کاملSelection of Clinical Trials
Approved: Major Professor: Eugene Fink, Ph.D. Assistant Professor, Computer Science and Engineering
متن کاملAdaptive design and estimation in randomized clinical trials with correlated observations.
Clinical trial designs involving correlated data often arise in biomedical research. The intracluster correlation needs to be taken into account to ensure the validity of sample size and power calculations. In contrast to the fixed-sample designs, we propose a flexible trial design with adaptive monitoring and inference procedures. The total sample size is not predetermined, but adaptively re-e...
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ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2018
ISSN: 0277-6715
DOI: 10.1002/sim.7925